Greenville is a town in Piscataquis County, Maine, United States. The population was 1,646 at the 2010 census. Greenville is the historic gateway to the north country and a center for outdoor recreation in the area.

Greenville is located on Moosehead Lake—the state’s largest lake, at 40 miles long and 20 miles wide. You can go fishing or boating on the lake or venture to the middle of the lake to hike up to the top of Mount Kineo, with its 763-foot sheer cliff. Here you can also see one of the world’s largest masses of rhyolite, a light-colored volcanic rock found in select spots throughout the state. This area is also one of the best places to spot moose—during the “Moosemania” festival in spring, moose sightings are in the hundreds. You can hire a guide to take you on a moose safari or other outdoor adventure, such as a fishing or dogsledding trip.  Ice fishing, cross-country skiing and snowmobiling are popular winter activities.

This climatic region is typified by large seasonal temperature differences, with warm to hot (and often humid) summers and cold (sometimes severely cold) winters. According to the Köppen Climate Classification system, Greenville has a humid continental climate. Located north of the 45th parallel on a line with Montreal, Greenville, in climate and vegetation, has more in common with the northernmost United States and southern Canada than it has with southern Maine.